Welcome to the Integrative Neurophysiology Laboratory Website

Mission Statement

To identify the neuromuscular mechanisms of human fatigue and physical disability.


The current research at INPL focuses on developing a clearer understanding of fatigue and disability and the treatments in people with Multiple Sclerosis (MS). We also focus on investigating new therapeutic approaches to neurological diseases.

The current basic laboratory research focuses on the following areas:

  1. Investigating the effects of cannabis use in patients with MS on motor and cognitive functions.
  2. Exploring the positive and negative effects of cannabis on quality of life and disability in neurological diseases (e.g. Parkinson’s disease, Multiple Sclerosis, Dementia).
  3. Clarifying the origins of MS related fatigue.
  4. The use of non-invasive neuroimaging techniques (Positron Emission Tomography, Computed Tomography, Magnetic Resonance Imaging) to examine the CNS–skeletal muscle interaction at a whole-body level.

Lab News

  • Dr. Rudroff and his colleagues from Anschutz Medical Campus, Denver, Drs. Jennifer Kwak (Nuclear Medicine) and Justin Honce (Neuroradiology) received a grant from the Colorado Translational Research Imaging Center (C-TRIC) to investigate "Effects of regular cannabis smoking on resting brain function in people with multiple sclerosis: An observational FDG-PET study".
  • Dr. Rudroff and Neurologist Dr. Shaffer presented "Medical Marijuana and Multiple Sclerosis" at the MS & Men Conference on Sept. 10, 2016 at Coors Field, Denver, CO.
  • Our research study Medical marijuana and its effects on motor function in people with Multiple Sclerosis: An observational case-control study has been approved by the IRB.
  • Brian Shapiro, Founder/CEO of CannaSaver www.cannasaver.com supports our research on Medical Marijuana and Multiple Sclerosis.

Names left to right: INP Lab: Nathan Ketelhut, Thorsten Rudroff and John Kindred